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Bradykinins degradation is carried out by several enzymes: angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP), aminopeptidase P (APP), dipeptidyl peptidase IV (DPP-IV), and kininase I [8]
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Single and dual agonists The fundamental difference between these two molecules is that semaglutide is a GLP-1 agonist, i.e., it has a strong structural similarity (95%) with this hormone and specifically activates its receptor, while tirzepatide is a dual agonist, i.e., it has a hybrid structure that allows it to activate both GLP-1 and GIP receptors (Figure 2)
---------- CARNITOR (levocarnitine) is a carrier molecule in the transport of long-chain fatty acids across the inner mitochondrial membrane
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